Chapter 14
Self-Quiz
Unit 3: Genetics
DNA
Review
DNA is the hereditary material of organisms. It is a two-stranded molecular
"ladder"
twisted into a
. DNA is made of
building blocks. Each
nucleotide
consists of a
backbone attached to a
. The sugar in DNA is a 5-carbon
, with the nitrogen
base
attached to the 1
'
carbon and the phosphate group attached to the 5
'
carbon.
The sugar-phosphate
backbone
forms the "sides" of the ladder with strong
bonds.
The 3
'
carbon bonds with the phosphate group of the next nucleotide. The two sides are
since the sugar rings are oriented in opposite directions.
The nitrogenous bases form the "rungs" that are held together by weak
bonds
that form between specific bases on opposite strands. There are four nitrogenous bases in DNA:
(A),
(T),
(G), and
(C). T always pairs with A, and C always pairs with G.
Variation in DNA base sequences is responsible for the
different
of genes, and thus serves as the basis for genetic diversity and inheritance.
The specific pattern of base
in DNA provides the mechanism for DNA
replication.
An existing strand serves as a
for the formation of a new
strand.
DNA
replication
requires
enzymes
such as
which unwinds the double helix by breaking the hydrogen bonds,
which "primes" the replication with starter RNA nucleotides, DNA
which adds DNA nucleotides to each template strand on short fragments in the 5
'
to 3
'
direction, and
which joins the fragments together to form new
strands.
DNA can be
altered
by numerous environmental factors, such as
light and
, or by
errors
during the replication process. DNA repair
enzymes
can correct most of the errors by removing the damaged
strand
and replacing that strand by base-pairing with the remaining strand.
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Apr 20, 2006
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